Continuous signals
Wearables produce increasingly detailed measurements and scores. We study what those signals represent, how to validate them against meaningful reference measurements, and what they add to clinical assessment.
A physician-led applied medical AI lab
We’re physician-scientists exploring what medicine can become in the age of AI.
We build tools that connect health data with scientific evidence, establish which signals matter clinically, and help translate that understanding into care.
Explore the work
We develop AI tools for clinical work and study how physiological and genomic information can inform care. Our research examines what these signals reveal, how reliably they can be interpreted, and what they add to existing clinical knowledge.
Wearables produce increasingly detailed measurements and scores. We study what those signals represent, how to validate them against meaningful reference measurements, and what they add to clinical assessment.
Your genome adds information that can sharpen the clinical picture. We interpret it alongside your history, measured health, and goals to refine recommendations and identify what deserves closer attention.
Explore the genomics workWe build agents for healthcare tasks and tools for working across scientific literature and clinical records. Our focus is on useful capabilities that physicians can inspect, evaluate, and bring into practice.
Medical observability
Wearables, laboratory tests, imaging, genomics, and clinical encounters each capture part of an individual’s health. We’re building systems that connect this information across time, so it can be interpreted together.
As physician-builders, we develop these systems and establish the clinical significance of their outputs in a virtuous loop. Clinical questions shape the tools, and what we learn from them informs care.
Signals in context
We build tools to distinguish meaningful physiological changes from measurement noise and everyday variation. Bringing those signals together with genomic and clinical context helps us understand the foundations of an individual’s health.
We’re physician-scientists who write software, conduct research, and care for patients. PLC brings those parts of our work together.
About usWe care for a select group of patients, bringing clinical history, genomic context, and measured physiology into a plan for preserving health.
Clinical context
A useful model helps us understand what is happening and what to do next. We consider its insights alongside your history, daily life, and goals to decide what deserves attention.
The goal is better health, not simply a better score. Together, we choose priorities that support your health now and help preserve it over time.
N-of-1 experimentation
Research gives us a starting point. Your biology, daily life, and experience help shape what comes next.
We work together to ask useful questions, make considered changes, and understand how you respond. Over time, that becomes a clearer picture of what helps you feel and function well.
Our experience in acute care shapes our interest in what can be done earlier. Prevention is an opportunity to act before illness demands attention, while remaining responsive to the health questions a person faces today.

Why longevity
For us, longevity means working toward more time in good health: staying active, capable, and engaged in the things that matter to you.
We collaborate with teams developing healthcare AI and tools for understanding health. We help frame clinical questions, design studies, and examine what an output would mean in practice.
Discuss a collaborationOur consulting work is scientific and technical. We do not provide care under a client’s brand or staff a client’s clinician panel.